Description
RABIROUND tablets contains Rabeprazole
Rabeprazole is a proton pump inhibitor.
Rabeprazole belongs to a group of antisecretory compounds that do not exhibit anticholinergic or H2receptor antagonist properties. They suppress gastric acid secretion by inhibiting gastric H+K+ ATPase at the secretory surface of the gastric parietal cells. Because this enzyme is regarded as an acid pump within the parietal cell, Rabeprazole has been characterized as a gastric proton pump inhibitor.
Rabeprazole blocks the final step of gastric acid secretion. In the gastric parietal cells, Rabeprazole is protonated, accumulated and is transformed to an active sulfonamide. When studied invitro, Rabeprazole is chemically activated at ph 1.2 with a half-life of 78 seconds. It inhibits acid transport in porcine gastric vesicles with a half-life of 90 seconds.
INDICATIONS
Duodenal ulcer
Healing and symptom relief of benign gastric ulcer.
GERD
Zollinger-Ellison syndrome.
CONTRAINDICATION
Hypersensitivity
SPECIAL PRECAUTION
Severe hepatic impairment and lactation.
DRUG INTERACTIONS
Elimination half –life of digoxin increases on administration of Rabeprazole.
ADVERSE EFFECTS
Headache, diarrhea, rash, infection and flu like symptoms
This should be administered strictly with the prescription and advise of medical practitioners only.