Description
• Mechanism: It works by blocking the H+/K+-ATPase enzyme (gastric proton pump) in the stomach lining, which prevents the final step of acid production.
• Uses:
o Treatment and healing of erosive esophagitis (damage to the esophagus from stomach acid).
o Management of GERD symptoms, including heartburn and acid regurgitation.
o Healing and prevention of stomach and duodenal ulcers, sometimes used in combination with antibiotics to treat H. pylori infections.
o Management of conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome.
o Prevention of gastric ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) long-term.
• Administration: It is typically taken once daily, at least one hour before a meal, swallowed whole with a glass of water. The tablets or capsules should not be chewed or crushed.
• Onset of Action: It may take 2 to 3 days for the medicine to start working, and up to 4 weeks for the full effect to be felt. It is not intended for immediate heartburn relief.
Common Side Effects
Most side effects are mild and temporary.
• Headache
• Diarrhea or constipation
• Stomach pain, gas, or nausea
• Dry mouth
Important Precautions and Warnings
Consult a doctor if you experience severe side effects or if symptoms persist.
• Long-Term Use: Prolonged use (over a year) may increase the risk of bone fractures, Clostridioides difficile infection (severe diarrhea), and low levels of magnesium and Vitamin B12 in the blood.
• Drug Interactions: Esomeprazole can interact with certain medications, including the blood thinner warfarin, some HIV medications (atazanavir, nelfinavir), and the antiplatelet drug clopidogrel.
• Serious Symptoms: Seek immediate medical help if you experience chest pain, unexplained weight loss, difficulty swallowing, vomiting blood, or black, tarry stools, as these may indicate a more serious underlying condition.
• Pregnancy/Breastfeeding: Consult your doctor before using this medication if pregnant or breastfeeding
