Description
ANTIBACTERIAL SPECTRUM
Being a third-generation cephalosporin, Cefixime offers excellent activity against gm-ve bacteria apart from its action against gm+ve organisms. It is active against most streptococci, E coli, most staphylococci, Proteus, Klebsiella, H. influenza, N.gonorrhoea, M. catarrhalis, and Salmonella.
MECHANISM OF ACTION
Like other beta lactam compounds, LIMFIX acts by interfering with the synthesis of peptidoglycan component of bacterial cell wall. It acts by binding to and inhibiting the specific target proteins located on the bacterial cell membrane.
LIMFIX has strong affinity for PBP, so offers faster lytic activity compared to other cephalosporins. LIMFIX is highly stable in the presence of beta lactamase enzymes. Many organisms resistant to penicillin and some other cephalosporins due to beta lactamase may be susceptible to LIMFIX
INDICATIONS
- Cefixime is indicated in the treatment of infections caused by susceptible strains of microorganisms.
- Typhoid fever
- Bronchitis
- Acute exacerbation of chronic bronchitis
- Pneumonia
- Pharyngitis and tonsillitis
- Uncomplicated and complicated UTI
- Otitis media
- Uncomplicated gonorrhea
- Sequential treatment after initial IV treatment with parenteral cephalosporins.
CONTRAINDICATIONS AND PRECAUTIONS
Cefixime is contra indicated in-patients with known allergy to cephalosporins. Cefixime should be given with caution in-patients who have shown hypersensitivity to penicillin and other drugs.
Cefixime should be given with caution in patients with markedly impaired renal function and patients with history of gastro intestinal diseases particularly colitis.
This should be administered strictly with the prescription and advise of medical practitioners only.
