Description
MECHANISM OF ACTION
Third generation cephalosporin with broad spectrum gram – ve activity has lower efficacy against gram positive organisms but higher efficacy against resistant organisms; highly stable in presence of B-lactamases (penicillinase and cephalosporinase) of gram –ve and gram +ve bacteria.
Bactericidal activity results from inhibiting cell wall synthesis by binding to 1 or more penicillin binding proteins; exerts antimicrobial effect by interfering with synthesis of peptidoglycan (major structural component of bacterial cell wall); bacteria eventually lyse because activity of cell wall autolytic enzymes continues while cell wall assembly is arrested.
Indications
• Bacteraemia
• Septicaemia
• Serious respiratory tract infections
• Gonococcal meningitis
• Bone
• Joint urinary tract
• Gynaecologic
• Intra-abdominal
• Skin
infections caused by susceptible organisms
This should be administered strictly with the prescription and advise of medical practitioners only.
