Description
MECHANISM OF ACTION
Aceclofenac exerts its action on mediators of inflammation. It inhibits the synthesis of inflammatory cytokines interleukin 1b and tumour necrosis factor, and inhibits prostaglandinE2 production. It stimulates glycosaminoglycan [GAG] synthesis as seen in invitro experiments. Increased synthesis of GAG an important macromolecule of the extracellular matrix aids in repair and regeneration of articular cartilage. Thus, Aceclofenac has positive effects on cartilage anabolism combined with modulating effect of matrix catabolism. NSAIDs that inhibit GAG synthesis would hasten the decline of articular cartilage, which may deteriorate the condition being treated. Aceclofenac inhibits the neutrophil accumulation at the inflammatory sites in the early phase and thus blocks the proinflammatory action of neutrophils.
Paracetamol, also known as acetaminophen and APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief.
DOSAGE & ADMINISTRATION
One tablet BID.
