Description
Ondansetron is a serotonin5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy. Ondansetron is also effective in controlling post-operative (PONV) and post-radiation nausea and vomiting, and is a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis.
Its effects are thought to be on both peripheral and central nerves. LIMESET reduces the activity of the vagus nerve, which activates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.
MECHANISM OF ACTION
Ondansetron is a carbazole compound structurally similar to serotonin
Highly selective competitive antagonist
Serotonin neurotransmission at the 5-HT3 receptor
Peripheral (vagal nerve terminals) afferent stimuli from GIT & Central action in the CTZ Preventing or Reducing Vomiting
INDICATIONS
Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy.
Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
Prevention of postoperative nausea and or vomiting. As with other antiemetics, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and or vomiting must be avoided postoperative.
This should be administered strictly with the prescription and advise of medical practitioners only.
