Description
Antibiotic Class:
Beta-lactam/beta-lactamase inhibitor
Antimicrobial Spectrum:
Staphylococcus aureus (methicillin susceptible), Coagulase negative Staphylococci,
Streptococcus pneumoniae (penicillin susceptible), Streptococcus spp., Haemophilus influenzae,
Moraxella catarrhalis, Neisseria meningitides, Neisseria gonorrhoeae, Enterobacteriaceae, E.
coli, Pseudomonas aeruginosa
MECHANISM OF ACTION
The beta-lactamase inhibitors are recognized as substrates for the beta-lactamases produced by bacteria. This allows the actual beta-lactams to attack the bacterial cell wall by binding to penicillin binding proteins
Dosage: IV: Complete listing on Table 6
Dosing in adults: Mild/Moderate: 2.25-3.375g q6h Severe: 3.375-4.5g q6h
Dosing in paediatrics: Not indicated in children < 12 years of age Table 8
Disease state based dosing: Renal failure: CrCl > 40mL/min: 3.375g q4-6h CrCl 20-40mL/min: 2.25g q6h CrCl < 20mL/min: 2.25g q8h
Hepatic failure: Dosage adjustment not necessary Table 9
Dosing during Continuous Renal Replacement Therapy CVVH (Continuous venovenous hemofiltration): 2.25g IV q6h CVVHD (Continuous venovenous hemodialysis): 2.25-3.375g IV q6h CVVHDF (Continuous venovenous hemodiafiltration) 2.25g-3.375g IV q6h Note: CVVH is mainly for fluid removal alone. Many institutions will employ more CVVHD or CVVHDF which combine dialysis with fluid removal.
Indications
♦ LRTI.
♦ Intra-abdominal infections.
♦ Pelvic infections.
♦ Skin and skin- structure infections.
♦ Urinary tract infections.
♦ Bacterial septicaemia.
This should be administered strictly with the prescription and advise of medical practitioners only.
